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  1. relating to or causing very serious infectious disease that spreads quickly and kills large numbers of people: Smallpox is clearly the worst of the pestilential diseases. In the story, a pestilential fog envelops every population centre in the country.

  2. 1. a. : causing or tending to cause pestilence : deadly. b. : of or relating to pestilence. 2. : morally harmful : pernicious. 3. : giving rise to vexation or annoyance : irritating. pestilentially. ˌpe-stə-ˈlen (t)-sh (ə-)lē. adverb. Synonyms. abrasive. aggravating. annoying. bothersome. carking. chafing. disturbing. exasperating.

  3. Pestilential definition: producing or tending to produce pestilence. . See examples of PESTILENTIAL used in a sentence.

  4. Infectious, plague-causing, and definitely disease-bearing: If it's likely to bring along pestilence, then it's pestilential. Today we know that dirty hands, unclean water, and bubonic plague-carrying rats can all be potentially pestilential.

  5. relating to or causing very serious infectious disease that spreads quickly and kills large numbers of people: Smallpox is clearly the worst of the pestilential diseases. In the story, a pestilential fog envelops every population center in the country.

  6. (pestɪlenʃəl ) 1. adjective [ADJECTIVE noun] Pestilential is used to refer to things that cause disease or are caused by disease. [formal] ...people who were dependent for their water supply on this pestilential stream. ...a pestilential fever. 2. adjective [ADJECTIVE noun]

  7. 1. producing or tending to produce pestilence. 2. pertaining to or of the nature of pestilence, esp. bubonic plague. 3. harmful or pernicious. 4. annoying or troublesome. Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved. Thesaurus.