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Tanya Barauskas Dorff, M.D., is a professor in the Department of Medical Oncology & Therapeutics Research and serves as division chief of the Genitourinary Disease Program at City of Hope. She is an internationally recognized leader in prostate cancer, and is renowned for her work in other genitourinary tumor types, including kidney, bladder ...
- Department of Medical Oncology & Therapeutics Research
Additionally, the department collaborates with City of...
- Department of Medical Oncology & Therapeutics Research
Tanya B. Dorff, MD, is associate professor of medical oncology and therapeutics research and section chief of the Genitourinary Disease Program at City of Hope, a top-ranked National Cancer Institute – designated Comprehensive Cancer Center in Duarte, CA.
Stephen Hartley Dorff Jr.[2] (born July 29, 1973) is an American actor. Starting his film career as a child appearing in the cult horror film The Gate (1987), Dorff first rose to prominence playing Stuart Sutcliffe in Backbeat (1994) and then gained further mainstream attention for portraying Deacon Frost in Blade (1998).
- Why Did You Become A Doctor?
- How Is Chemotherapy Used Today For Men with Prostate Cancer?
- With Which Other Kinds of Agents Is Chemotherapy Frequently combined?
- Why Do You Think That is? Is It Just That The Combination Is Too Toxic?
- How Long Are They Fasting Before They Start The Chemo? What Does That Look like?
- Can You Explain What That is?
- There’S No Way to Predict Who Might Suffer from That Or Not?
- Equal Efficacy and Side Effects Are A Huge Issue For Men.
- What Combinations with Taxotere (Docetaxel) Do You Think Will Work Best?
- What About Favorite Sequences?
Dr. Tanya Dorff: When I was around three years old, I decided that what I wanted to do with my life was help people. And being a concrete thinker as a three-year-old, I felt like being a doctor was the only way to do that.
Dr. Dorff: When I started treating prostate cancer, chemo was pretty much our only tool besides standard hormone therapy. It worked, but it was sort of end-of-the-line. People didn’t tolerate it very well, in part, because we used it in really advanced cases. Then, the drugs like Zytiga (abiraterone) and Xtandi (enzalutamide) came out, dramatically...
Dr. Dorff: Combinations with Taxotere (docetaxel) have never yet been successful in prostate cancer. There was Taxotere (docetaxel) with a high-dose Vitamin D, which was not only negative in that it failed to improve outcomes, but patients who received the combination actually fared worse. There was Taxotere (docetaxel) with Revlimid (lenalidomide)...
Dr. Dorff: I don’t know. I don’t think it’s too toxic. All of these combinations go through safety before they go into Phase III, and you can combine them safely. I do not understand why combinations fail. Maybe it goes back to biology. Why would the combination succeed? You want something that makes the chemo work better, or you want the chemo to ...
Dr. Dorff: They fast for 48 hours on a fasting mimic diet, which means they get vegetable broth and an energy drink. So, it’s a liquid, low calorie diet. It’s hard, so that’s part of why the study is still ongoing. In our earlier trial, in which we did fasting with platinum chemo for up to 72 hours (48 before and 24 after the chemo dose), people re...
Dr. Dorff: It’s damage to the small nerves out in the fingers and toes that can manifest as numbness or pins and needles, burning kinds of discomfort. That can be permanent.
Dr. Dorff: It’s not a complete no. We know patients who already have some preexisting neuropathy, whose nerves are already damaged, are more susceptible, for instance patients with diabetic nerve damage. That’s one reason we might try to get them Jevtana (cabazitaxel) instead of Taxotere (docetaxel) because Jevtana (cabazitaxel) doesn’t impact the ...
Dr. Dorff: Patients really worry about hair loss. I don’t think we’re impacting that with the diet, unfortunately. That is reversible. They also complain about the taste changes and mouth sensitivity because that really impacts eating.
Dr. Dorff: The ongoing combinations that I think people are still interested in are platinum with taxane and carboplatin with Jevtana (cabazitaxel). That’s an important combination for the more aggressive variants. Part of how we think Taxotere (docetaxel) chemotherapy works is that it interferes with antigen receptor (AR) translocation in the cell...
Dr. Dorff: We know that after you’ve had Zytiga (abiraterone) or Xtandi (enzalutamide), you can induce the androgen receptor splice variants such as AR-V7. These are associated with less responsiveness to Zytiga (abiraterone) or Xtandi (enzalutamide). Patients might want to go from Zytiga (abiraterone) straight to Xtandi (enzalutamide), but we know...
Dr. Tanya B. Dorff is a Oncologist in Duarte, CA. Find Dr. Dorff's phone number, address, insurance information, hospital affiliations and more.
- Medical Oncology and Therapeutics Research, Duarte, 91010
- (626) 256-4673
- Yes, you can book an appointment with Dr. Dorff online today. It's simple, secure, and free.
- Call Dr. Dorff for more information on telehealth services.
- We’ve published patient experience ratings for Dr. Dorff in 6 key categories based on 19 reviews. See ratings .
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- Dr. Dorff's office is located at Medical Oncology and Therapeutics Research, Duarte, CA. View the map .
- Oncologists diagnose and treat cancers of all types. They are skilled at using diagnostic tools, including biopsies, endoscopies, x-rays and other...
Mar 10, 2023 · Tanya Dorff, MD, medical oncologist, associate clinical professor, Department of Medical Oncology & Therapeutics Research, City of Hope, discusses key data supporting the use of intensified...
Dr. Shanda R. Dorff, MD, FAAFP. I decided at 7 years old that I wanted to be a physician and began researching different paths to achieve my goal as well as started shadowing in the area hospitals at age 13. I was a Valedictorian of my graduating class from Ozark, MO.
