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In biochemistry, a Ramachandran plot (also known as a Rama plot, a Ramachandran diagram or a [φ,ψ] plot), originally developed in 1963 by G. N. Ramachandran, C. Ramakrishnan, and V. Sasisekharan, is a way to visualize energetically allowed regions for backbone dihedral angles ψ against φ of amino acid residues in protein structure.
Feb 23, 2024 · Ramachandran plot is the plot of angles called psi (ψ) and phi (φ) of the residues (commonly known as amino acids) present in a peptide. It assess the stereochemical quality of protein structures by plotting the phi (ϕ) and psi (ψ) dihedral angles of amino acid residues.
A special way for plotting and visualization of protein torsion angles was introduced by Ramachandran and co-authors and has since then been called the Ramachandran plot. In the Ramachandran plot, we can view the distribution of torsion angles in a protein structure (image below).
The Ramachandran plot is a foundational concept used in biochemistry courses to describe the basic elements of protein structure, but in most cases the approach is based on a decades old view of secondary structure types summarized in the IUPAC nomenclature from 1970 .
The Ramachandran plot shows the statistical distribution of the combinations of the backbone dihedral angles ϕ and ψ. In theory, the allowed regions of the Ramachandran plot show which values of the Phi/Psi angles are possible for an amino acid, X, in a ala-X-ala tripeptide (Ramachandran et al., 1963 ).
Mar 12, 2019 · A Ramachandran plot, also known as a Ramachandran diagram or a [φ,ψ] plot, was originally developed by Gopalasamudram Ramachandran, an Indian physicist, in 1963. Ramachandran Plot is a way to visualize dihedral angles ψ against φ of amino acid residues in protein structure.
Nov 30, 2010 · The Ramachandran plot is a plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in a peptide. In sequence order, φ is the C (i-1),N (i),Ca (i),C (i) torsion angle and ψ is the N (i),Ca (i),C (i),N (i+1) torsion angle.
Learn Ramachandran Plot with free step-by-step video explanations and practice problems by experienced tutors.
Aug 4, 2016 · The Ramachandran plot is an important way of describing protein secondary structure. (a) The state of a residue within a peptide (top) and a peptoid (bottom) can be largely specified by the two dihedral angles ϕ and ψ.
His discovery of the triple helical structure of collagen published in Naturein 1954 and his analysis of the allowed conformations of proteins through the use of the ‘Ramachandran plot’ rank among the most outstanding contributions in structural biology.
