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The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base. The reaction produces a β-keto ester or a β-diketone. It is named after Rainer Ludwig Claisen, who first published his work on the reaction in 1887.
The Claisen condensation reaction is an organic coupling reaction that results in the formation of a C-C bond between either a single ester and one carbonyl compound or between two esters. The reaction proceeds when a strong base is present and the product of the reaction is a beta-keto ester or a beta-diketone.
Jan 23, 2023 · Because esters can contain α α hydrogens they can undergo a condensation reaction similar to the aldol reaction called a Claisen Condensation. In a fashion similar to the aldol, one ester acts as a nucleophile while a second ester acts as the electrophile.
Jan 15, 2023 · write a detailed mechanism for a Claisen condensation reaction or its reverse. identify the product formed in a given Claisen condensation reaction. identify the ester and other reagents needed to form a given β ‑keto ester by a Claisen condensation reaction.
The Claisen Condensation between esters containing α-hydrogens, promoted by a base such as sodium ethoxide, affords β-ketoesters. The driving force is the formation of the stabilized anion of the β-keto ester.
Sep 14, 2020 · The Claisen condensation is one of the fundamental reactions of esters. In the Claisen condensation, an ester (2 equivalents) is treated with a base (1 equivalent); the product is a called “ beta-keto” ester, since a ketone is located two carbons away (beta) from the ester carbonyl. It forms a new C-C bond and breaks a C-O and C-H bond.
For instance, ethyl acetate yields ethyl acetoacetate on base treatment. This reaction between two ester molecules is known as the Claisen condensation reaction. (We’ll use ethyl esters, abbreviated “Et,” for consistency, but other esters will also work.)
