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Apr 30, 2009 · Today we’ll start with the basic structure of influenza virus, illustrated above. The influenza virion (as the infectious particle is called) is roughly spherical. It is an enveloped virus – that is, the outer layer is a lipid membrane which is taken from the host cell in which the virus multiplies.
Sep 9, 2008 · The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift.
Jul 22, 2019 · Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP ...
Antigenic differences exhibited by two internal structure proteins (NP and M) are used to divide influenza viruses into types A, B, and C. Influenza viruses A and B cause seasonal epidemics, whereas type C causes mild respiratory illness.
May 13, 2010 · The influenza A and B virus genomes consist of 8 separate segments, each coding for 1 or several functionally important proteins required for virus entry, replication or virus structure. HA binds to its cellular receptor, sialic acid (N-acetyl-neuraminic acid).
Sep 17, 2021 · The influenza virus is an enveloped virus belonging to the Orthomyxoviridae family. There are four genera of influenza virus that infect vertebrates: influenza virus A, B, C, and D which are distinguished based on antigen differences in their matrix protein and nucleoprotein.
Jun 28, 2018 · This Primer discusses the biological features of influenza viruses, their effects on human and animal health and the mitigation strategies to reduce the burden of this disease.
The influenza A virus genome consists of eight segments of single-stranded negative sense vRNA. Each segment contains conserved 5′ and 3′ termini, segment-specific untranslated regions (UTRs), and at least one large open-reading frame (ORF).
Jan 1, 2014 · The three influenza virus types, A, B, and C (IAV, IBV, ICV), are RNA viruses with a negative-sense, single-stranded, and segmented RNA genome (Webster et al. 1992 ). The classification into A, B, and C is based on the immunologically distinct nucleoprotein and matrix protein antigens.
Jan 27, 2017 · The Influenza A viral genome consists of eight, single negative-strand RNAs that can range between 890 and 2340 nucleotides long. Each RNA segment encodes one to two proteins. Find more about the replication of Influenza A virus here. Influenza A virus particles. Courtesy of Audray Harris, Bernard Heymann and Alasdair C. Steven, LSBR, NIAMS, NIH.
