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Jun 17, 2024 · The Gene Ontology (GO) knowledgebase is the world’s largest source of information on the functions of genes. This knowledge is both human-readable and machine-readable, and is a foundation for computational analysis of large-scale molecular biology and genetics experiments in biomedical research.
This makes communication and sharing of data more difficult. The Gene Ontology project provides an ontology of defined terms representing gene product properties. The ontology covers three domains: cellular component, the parts of a cell or its extracellular environment;
An ontology is a formal representation of a body of knowledge within a given domain. Ontologies usually consist of a set of classes (or terms or concepts) with relations that operate between them. The Gene Ontology (GO) describes our knowledge of the biological domain with respect to three aspects: Molecular Function.
The Gene Ontology defines the “universe” of possible functions a gene might have, but it makes no claims about the function of any particular gene. Those claims are, instead, captured as “GO annotations.”
The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function; Biological process; Cellular component; A variety of groups, including UniProtKB curators, use GO terms to annotate gene products in a computationally tractable manner. UniProt lists the annotated GO terms in the 'Function ...
The Gene Ontology knowledgebase provides a computational representation of our current scientific knowledge about the functions of genes (or, more properly, the protein and non-coding RNA molecules produced by genes) from many different organisms, from humans to bacteria.
The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
