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  1. www.ncbi.nlm.nih.gov › home › aboutAbout NCBI - National Center for Biotechnology Information

    Sep 25, 2024 · NCBI is streamlining the terminology around our reference genomes. We currently have a small set of genomes collectively called representatives and an even smaller set called references.

    • Our Mission

      As a national resource for molecular biology information,...

    • Statistics

      Gene's statistics site reports the total current records per...

  2. ncbiinsights.ncbi.nlm.nih.gov › 2024/09/30 › ligandViewing Ligand-Protein Interactions in iCn3D - NCBI Insights

    2 days ago · You are now able to see the interactions of an embedded ligand (such as the drug Gleevec in the protein ABL2) within iCn3D. In the image below, the left panel shows Gleevec colored by atom type and the interacting ABL2 protein residues colored in magenta. The right panel displays Gleevec as a 2D structure with interacting protein residues shown ...

  3. pubmed.ncbi.nlm.nih.gov › 39227063Developing clinical prediction models: a step-by-step guide

    Sep 4, 2024 · This article presents a step-by-step guide to help researchers develop and evaluate a clinical prediction model. The guide covers best practices in defining the aim and users, selecting data sources, addressing missing data, exploring alternative modelling options, and assessing model performance.

  4. www.ncbi.nlm.nih.gov › gene › statisticsStatistics - Gene - NCBI

    Sep 25, 2024 · Gene's statistics site reports the total current records per taxonomy identifier per time period. These numbers should not be interpreted as the number of known functional genes, because Gene also maintains information on gene predictions, pseudogenes, and mapped phenotypes. These records are included in the total. Species / Taxonomy ID.

  5. pubmed.ncbi.nlm.nih.gov › 39330700Tofersen for SOD1 ALS - PubMed

    5 days ago · Tofersen, an antisense oligonucleotide that reduces expression of SOD1 via RNAase mediated degradation of SOD1 mRNA, has shown robust effects on ALS biomarkers. While a Phase III trial of tofersen failed to meet its primary end point, open label extension data suggests that tofersen slows progression of SOD1 ALS.

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  7. pubmed.ncbi.nlm.nih.gov › 39333267CNVoyant a machine learning framework for accurate and ...

    4 days ago · The precise classification of copy number variants (CNVs) presents a significant challenge in genomic medicine, primarily due to the complex nature of CNVs and their diverse impact on rare genetic diseases (RGDs). This complexity is compounded by the limitations of existing methods in accurately dis …

  8. www.ncbi.nlm.nih.gov › books › NBK279141Oral and Injectable (Non-Insulin) Pharmacological Agents for ...

    Sep 11, 2024 · While lifestyle changes such as dietary modification and increased physical activity can be very effective in improving glycemic control, over the long-term most individuals with Type 2 diabetes (T2DM) will require medications to achieve and maintain glycemic control. The purpose of this chapter is to provide the healthcare practitioner with an overview of the existing oral and injectable (non-insulin) pharmacological options available for the treatment of patients with T2DM. Currently ...

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