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- Dictionarydisregard/ˌdɪsrɪˈɡɑːd/
verb
- 1. pay no attention to; ignore: "the body of evidence is too substantial to disregard"
noun
- 1. the action or state of paying no attention to something: "blatant disregard for the law"
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Oct 18, 2004 · — impurity with relative retention at about 1.23: maximum 0.2 per cent, — any other impurity: maximum 0.1 per cent, — total: maximum 1.2 per cent, — disregard limit: 0.05 per cent. Should I disregard all the peaks below 0,05% including those specified (A, B,…I) and report them as “not detectedâ ...
Aug 11, 2014 · Re: Disregard limit in EP. by dlbenach » Tue Aug 12, 2014 12:08 pm. The isopulegol in Ref B is present at 0.01 uL/mL. Your test solution concentration is 20 uL/mL. 0.05% of 20 is 0.01. It is saying that you do not have to worry about any peaks less than 0.05% the concentration of your major peak.
May 23, 2013 · Measured values should be reported to the same number of significant figures as the limits. Therefore, 0.048% would be rounded to 0.05% and thus equal to an LOQ of 0.05% (note that 0.054% would also round to 0.05% and be reported the same way). If the LOQ had been stated as 0.050%, then 0.048% would not be rounded and would be reported as less ...
Nov 9, 2007 · Disregard limit & Method Validation. Milosh. Posts: 4. Joined: Fri Nov 09, 2007 7:08 pm. by Milosh » Tue Mar 18, 2008 8:48 pm. Hi! I am validating analytical methods onto HPLC and UPLC, and I have one question. I validate Pharmacopeiae HPLC method for impurities in which solution for disregard limit is given.
by ant_k » Wed Dec 04, 2013 10:15 am. Could you please advice in respect to an impurities calculation issue. We have developed / validated a method where impurities are calculated by the known formula: %imp= (Atest/Aref)* limit. Comparison of the % percentage for an unknown imp. with specific rrt with the %area presented in the chromatogram ...
Aug 11, 2005 · Our normal procedure is that if the sample has an unknown peak at a particular RT and the placebo chromatogram also shows a peak at that same RT±10%, we subtract the area due to the placebo from the area of the unknown peak in the sample chromatogram. Often we run a placebo at the begining and end of a sequence of runs and work with the mean ...
Jul 15, 2008 · I have a question about the condition for linear regression calibration curve (y=ax+b) to force through zero (y=ax). Generally, Forcing through zero has no big effect to relative coefficient (r) but it has indeed big effect to the value of sample in the lower concentrations range of calibration curve ( a few times difference between forcing ...
the solution and use this solution as the test solution. Reference solution. Dissolve 0.100 g of anhydrous formic. acid R in water R and dilute to 100.0mL with the same solvent. Dilute 1.0 mL of the solution to 100.0 mL with water R. Column: — size : l = 0.25-0.30 m, Ø = 4-8 mm;
Sep 3, 2004 · Traditionally we, have used external std method for all our impurity methods. This is the first one that we need to validate that uses Area %, and hence we have limited experience. My initial thought process was to validate the method as an external std method and then compare the results to the Area % calculation.
In principle, it's just what it sounds like: the amount of resolution between adjacent peaks at which the signals will drop to the baseline. In practice, many textbooks will state this value as Rs = 1.5 . This is a bit misleading; it is the resolution at which two equal-sized Gaussian peaks will have less than 1% overlap.
