Search results
11 hours ago · Our previous study demonstrated that HJURP, an oncogene upregulated in PCa cells, plays a role in tumor proliferation. Here, we expand these findings by elucidating a novel mechanism by which HJURP inhibits sensitivity to ferroptosis inducers in PCa cells via the PRDX1/reactive oxygen species (ROS) pathway in vitro and in vivo .
11 hours ago · Hepatic gluconeogenesis plays an important role in maintaining glucose homeostasis , and abnormally enhanced gluconeogenesis is one of the pathological features of T2DM [2, 3]. Thus, targeting ...
11 hours ago · 13 LAG-3 is an inhibitory receptor found primarily on activated CD4 +, CD8 +, and regulatory T cells (Treg), as well as on natural killer (NK) cells, and it binds the major histocompatibility complex class II (MHC-II). 14-16 FGL-1 may bind to the LAG-3 receptor independently of MHC-II interaction, leading to decreased proliferation and cytokine production in T cells.
11 hours ago · Invasive cells can undergo EMT through two distinct mechanisms: (i) elevated levels of MMPs in the tumor microenvironment can directly induce an EMT program, (ii) EMT can generate activated stromal-like cells that promote cancer progression through increased MMP production [18, 28]. Therefore, we investigated the anti-EMT properties of FAN by analyzing the altered expression of EMT-related proteins using western blot analysis, and assessing self-renewal, characteristics of cells undergoing ...
11 hours ago · TA systems in the SI are reported to be associated with virulence. For instance, the RelBE TA systems of the SI play a role in intestine colonization in a mouse model . However, evidence on the implication of other elements in the SI in the virulence of V. cholerae is lacking. To address this question, we performed a C. elegans killing assay.
11 hours ago · Probiotics, known for regulating gut microbiota, may aid those with overweight or obesity, but their mechanisms require more research. This study involved 75 overweight or obese young adults, randomly assigned to either a Bifidobacterium breve BBr60 (BBr60) group or a placebo group. Both groups received diet guidance and took either BBr60 (1 × 1010 CFU/day) or a placebo for 12 weeks. Researchers analyzed body composition, serum glucose, lipids, liver and kidney function, comprehensive ...
11 hours ago · MpPUB9 consists of 420 amino acids and contains a U-box domain at the N-terminus and five tandem ARM repeats at its C-terminus (Fig. 1b).It has been reported that the U-box domain comprises highly conserved c. 70 amino acid residues (Azevedo et al., 2001; Hatakeyama & Nakayama, 2003).
