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Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the first antibody to appear in the response to initial exposure to an antigen; causing it to also be called an acute phase antibody.
Dec 15, 2022 · Immunoglobulin M antibodies (IgM) are our first-line defense against a many infections & can indicate of disease. Learn more about high & low IgM levels.
Jan 23, 2024 · Immunoglobulin M is the antibody formed during the initial response to an antigen or microbe. Following stimulation of antigen, IgM-producing plasma cells migrate from the lymph node to bone marrow, where they turn into long-lived plasma cells.
Sep 19, 2023 · Immunoglobulin M: Your body makes IgM antibodies when you are first infected with new bacteria or other germs. They are your body's first line of defense against infections.
Dec 19, 2022 · IgM immunoglobulins are produced by plasma cells as part of the body's adaptive humoral immune response against a foreign pathogen. Resting mature yet naive, B lymphocytes express IgM as a transmembrane antigen receptor that functions as part of the B-cell receptor (BCR).
Oct 30, 2020 · Genetically conditioned mice which lack secreted or membrane bound IgM have underscored the importance of IgM in many infectious diseases. In this review, we highlight what is currently known about the role of IgM in B1 and B2 cell development, memory, and plasma cell generation, in and outside GCs.
Sep 8, 2020 · Immunoglobulins (Ig) or antibodies are glycoproteins produced by plasma cells. B cells are instructed by specific immunogens, for example, bacterial proteins, to differentiate into plasma cells.
Mar 22, 2023 · Immunoglobulin M (IgM) is the most ancient antibody class and key mediator of the primary immune response. New structures reveal how it binds to its only class-specific receptor (FcμR) and...
Feb 29, 2024 · Immunoglobulins, also called antibodies, are molecules produced by white blood cells that help your body defend against infections, autoimmune diseases, cancer, and other conditions. They bind...
Feb 6, 2020 · Immunoglobulin M (IgM) plays a pivotal role in both humoral and mucosal immunity. Its assembly and transport depend on the joining chain (J-chain) and the polymeric immunoglobulin receptor (pIgR), but the underlying molecular mechanisms of these processes are unclear.
