Search results
1 Introduction. Signaling pathways regulated by cyclic nucleotides are one of the well-studied central relay systems present in living organisms. Cyclic AMP was the first cyclic nucleotide signaling molecule discovered in 1958 by Earl Sutherland [2, 3 ]. Cyclic GMP was discovered in the early 1960s [ 4, 5 ].
The Cyclic AMP Pathway. Paolo Sassone-Corsi. + Author Affiliations. Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, California 92697. Correspondence: psc@uci.edu. Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first second messenger to be identified and plays fundamental roles in cellular ...
Jul 25, 2023 · Cyclic adenosine monophosphate is a small, hydrophilic molecule commonly known as cyclic AMP or cAMP, which is an important intracellular second messenger molecule regulated in many physiological processes. cAMP can trigger a cascade of events to influence cellular function through its interaction with protein effectors such as protein kinase A (PKA), exchange proteins activated by cAMP (EPACs), cyclic nucleotide-gated ion (CNG) channels, and hyperpolarization-activated cyclic nucleotide ...
The function of cyclic AMP helps with the regulation of glycogen, sugar, and lipid metabolisms. Once ATP transforms into cyclic AMP, it is able to activate the protein kinase A enzyme. This activation of the PKA enzyme allows cellular response to occur. Protein kinase A is an enzyme that is found in different types of cells and has a different ...
Oct 12, 2020 · Basic research into the ubiquitous cyclic nucleotide second messenger, cyclic 3′,5′-adenosine monophosphate (cyclic AMP), has developed an understanding of how small signalling molecules can mediate the intracellular actions of a wide range of cell surface receptors for hormones, neurotransmitters, and growth factors, as well as sensory stimuli [1,2]. Cyclic AMP is now recognized as a universal regulator of cellular function in a wide variety of organisms, including protozoa, plants, and ...
As such, cyclic AMP signalling has become an attractive target for drug development for the treatment for a large variety of diseases. This Special Issue of Cells is devoted to all aspects of cyclic AMP signalling in humans and other organisms. It will contain articles that collectively provide a balanced, state-of-the-art view of cyclic AMP ...
The second messenger, cyclic AMP, is made by the enzyme adenylate cyclase. Adenylate cyclase is a two‐component enzyme system. It ultimately catalyzes the cyclase reaction, but only when it is associated with the hormone‐bound receptor and a regulatory protein called a stimulatory G‐protein (guanylate nucleotide binding protein), which ...
