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  1. SUBSTANCE definition: 1. material with particular physical characteristics: 2. an illegal drug: 3. the most important…. Learn more.

  2. 1. a. : essential nature : essence. b. : a fundamental or characteristic part or quality. c. Christian Science : god sense 1b. 2. a. : ultimate reality that underlies all outward manifestations and change. b. : practical importance : meaning, usefulness.

  3. substance. /ˈsʌbstəns/ /ˈsʌbstɪns/ IPA guide. Other forms: substances. Any material that possesses physical properties is called a substance. The word also refers to the gist or main idea of something. If you remember the main point of a lesson, you've got the substance.

  4. Substance definition: that of which a thing consists; physical matter or material. See examples of SUBSTANCE used in a sentence.

  5. noun. us / ˈsʌb·stəns / substance noun (MATERIAL) Add to word list. [ C ] a material with particular physical characteristics: The pesticide contains a substance that is toxic to insects.

  6. A substance is a solid, powder, liquid, or gas with particular properties. Ethylene glycol is a poisonous substance found in antifreeze. The substance that's causing the problem comes from the barley. Synonyms: material, body, stuff, element More Synonyms of substance. 2. uncountable noun.

  7. 1. the tangible matter of which a thing consists. 2. a specific type of matter, esp a homogeneous material with a definite composition. 3. the essence, meaning, etc, of a written or spoken thought. 4. solid or meaningful quality. 5.

  8. Definition of substance noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.

  9. Substance definition: The most important part or idea of what is said or written; the essence or gist.

  10. noun. uk / ˈsʌbst ə ns / us. substance noun (MATERIAL) Add to word list. B2. a solid, liquid, or gas: a dangerous substance. illegal substances (= illegal drugs) Fewer examples. The athlete had taken a prohibited substance. Water is the most common substance on earth. The scientists seek to understand the structure of the substance.