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自宅に設置するコンテナ型ゴルフルーム「g_base（ジーベース）。ゴルファーの皆さまがいつでも集中してゴルフ時間を楽しめる、あなただけの秘密基地のようなプライベートゴルフ空間をご提供いたします。
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Sep 14, 2022 · Gerard Butler and Alan Siegel have teamed back up with Remi Adeleke, the star of upcoming action-thriller The Plane. The duo’s G-Base production company — behind The Plane, set for a January ...
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Jun 8, 2024 · DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based base editors for direct T editing (gTBE) and C editing (gCBE) by fusing Cas9 nickase (nCas9) with engineered human uracil DNA glycosylase (UNG) variants.
Apr 25, 2022 · In this study, we generated three different types of base editors termed TALEDs that enable A-to-G base editing in human mtDNA. We found that a full-length, non-toxic E1347A DddA tox variant functioned in cis (mTALEDs) or in trans (dTALEDs) with the deoxyadenosine deaminase derived from TadA fused to a custom-designed TALE DNA-binding protein to allow the deaminase to catalyze A-to-G conversions in double-stranded mtDNA.
Jan 23, 2024 · Huang, Qin, Shang et al. profile double-strand breaks (DSBs) generated by C-to-G base editors (CGBEs) and find that HMCES protects abasic sites and reduces CGBE-triggered DSBs.
