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Chinese hamster ovary ( CHO) cells are a family of immortalized cell lines [1] derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.
Chinese hamster ( Cricetulus griseus) ovary (CHO) cells, a mammalian cell line, are the equivalent of E. coli in research and biotechnology due to the extensive research and industrial attention they have received.
The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of the therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein.
- Shazid Md Sharker, Atiqur Rahman
- 2021
Aug 30, 2022 · Chinese hamster ovary cells (CHO) as the main production hosts offer a variety of advantages including robust growth and survival in a bioprocess environment.
- 10.1007/s00253-022-12123-6
- 2022
Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of producing high quality biologics exhibiting human-like post-translational modifications in gram quantities.
- Simon Fischer, Simon Fischer, René Handrick, Kerstin Otte
- 2015
Feb 17, 2021 · Several CHO cell lines have been developed to date; CHO-K1 and CHOK1SV are frequently used to produce biotherapeutics. CHO cell lines have been genetically engineered to increase productivity, reduce apoptosis, and improve glycosylation (Zhu et al. 2017).
Sep 28, 2020 · Abstract. Chinese hamster ovary (CHO) cells are the predominant production vehicle for biotherapeutics. Quantitative proteomics data were obtained from two CHO cell lines (CHO-S and CHO DG44)...