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The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. [1] [2] The basement membrane sits between epithelial tissues including mesothelium and endothelium, and the underlying connective tissue. [3] [4]
Sep 14, 2022 · The basement membrane, also known as basal lamina, is a thin, dense layer of extracellular matrix that lines most human tissues forming the supporting structure and scaffolding for epithelial tissue and separates different types of cells, such as nerve cells and muscle cells.
Oct 30, 2023 · The basement membrane is a thin, non-cellular, extracellular protein matrix that forms a specialized supporting sheet directly beneath the basal surfaces of all epithelial cells, separating them from underlying supporting tissues.
Basement membranes (BMs) are cell-adherent extracellular matrices widely distributed in metazoan tissues. First identified in skeletal muscle 176 years ago [ 1 ], elucidation of BM constituents, structure, functions and genetics has required advances in multiple fields stretched over many years.
The basement membrane is a thin but dense, sheet-like specialized type of extracellular matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly controlled spatial and temporal changes in its composition and structure contribute to the diversity of basement membrane functions.
Mar 20, 2017 · Basement membranes (BMs) are thin, dense sheets of specialized, self-assembled extracellular matrix that surround most animal tissues (Figure 1, top). The emergence of BMs coincided with the origin of multicellularity in animals, suggesting that they were essential for the formation of tissues.
Basement membranes are widely distributed extracellular matrices that coat the basal aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells.
Basement membranes of tissues are extracellular matrices separating epithelial cells from the underlying connective tissue. They function in cell support, act as semi-permeable filters and are thought to be involved in tissue morphogenesis and development.
The basement membrane separates endothelium from pericytes and astrocytes, two other cell types which regulate function of the neurovascular unit. The basement membrane is composed of different extracellular matrix structural proteins (e.g., collagen, laminin).
Jun 1, 2003 · The BASEMENT MEMBRANE (BM) is an amorphous, dense, sheet-like structure of 50–100 nm in thickness that was identified by transmission electron microscopy 1, 2, 3, 4, 5, 6.
