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Sep 8, 2023 · To overcome the harmful effects of DNA damage, cells have various systems such as DNA repair mechanisms, damage tolerance pathways, cell cycle checkpoints, and cell death pathways. These systems work together to repair or tolerate DNA damage, ensuring the overall survival and functionality of cells.
Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival.
DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a nucleobase missing from the backbone of DNA, or a chemically changed base such as 8-OHdG.
Feb 13, 2023 · This article series explores the pathways that detect and repair different types of DNA damage, highlighting new regulation mechanisms of the DNA damage response and the implications of...
Jul 9, 2021 · We understand presently that the term of “DNA repair” defines the biochemical and molecular biological processes of DNA damage removing and genomic integrity restoring, which including DNA...
DNA integrity is always under attack from environmental agents like skin cancer-causing UV rays. How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail?
Jul 10, 2020 · The genome is continuously threatened by different types of DNA lesions, such as abasic sites, mismatches, interstrand crosslinks, or single-stranded and double-stranded breaks. As a consequence, cells have evolved specialized DNA damage response (DDR) mechanisms to sustain genome integrity.
Jan 29, 2021 · DNA damage is a constant threat because nucleic acids are chemically unstable under physiological conditions and vulnerable to attack by endogenous and environmental factors. To combat this, all organisms possess highly conserved mechanisms to detect and repair DNA damage.
Jan 5, 2024 · Here, we present DNA Damage Atlas (DDA, http://www.bioinformaticspa.com/DDA/), the first large-scale repository of DNA damage and repair information. Currently, DDA comprises 6,030 samples from 262 datasets by 59 technologies, covering 16 species, 10 types of damage and 135 treatments.
Oct 18, 2023 · DNA damage refers to structural alterations to the DNA molecule that introduce deviations from its normal double helical structure. These abnormalities interfere with DNA replication and transcription, causing mutations.
