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Nov 22, 2012 · This document provides an overview of megaloblastic anemia, including its definition, causes, clinical features, investigations, treatment, and prognosis. Megaloblastic anemia is caused by impaired DNA synthesis and is characterized by megaloblastic erythropoiesis in the bone marrow.
Jan 11, 2018 · Megaloblastic anemia is a type of macrocytic anemia caused by a failure of DNA synthesis, resulting in asynchronous maturation of red blood cell nuclei and cytoplasm. The most common causes of megaloblastic anemia are vitamin B12 and folic acid deficiencies.
Sep 15, 2015 · This document discusses megaloblastic anemia, its causes, symptoms, and diagnostic tests. It begins by defining megaloblastic anemia as a group of disorders caused by deficiencies in vitamin B12 or folic acid. These deficiencies result in impaired DNA synthesis and defective cell maturation.
Download presentation. Presentation on theme: "MEGALOBLASTIC ANEMIAS"— Presentation transcript: 1 MEGALOBLASTIC ANEMIAS. 2 MEGALOBLASTIC ANEMIAS Causes. 1. Vit. B12 deficiency 2. Folic acid deficiency. 3 VITAMIN B12 AND FOLIC ACID-PHYSIOLOGIC CONSIDERATIONS.
Jan 5, 2020 · Objectives • Body stores and daily requirements of vitamin B12 and folate • Absorption of vitamin B12 and folate from the gut • Causes of vitamin B12 and folate deficiency • Hematological consequences of vitamin B12 and folate deficiency • Neurological sequelae of vitamin B12 deficiency • Diagnosis and management of megaloblastic ...
Aug 8, 2014 · Megaloblastic Anemias: Causes • Cobalamin (Vitamin B12) deficiency • Folic acid (folate) deficiency • Anti-folate drugs: Methotrexate, trimethoprim/sulfa antibiotics • Other drugs: Nucleoside inhibitors (zidovudine [AZT])
H.A. MWAKYOMA, MD. 2 Megaloblastic Anemia Most common causes are Folate and B12 deficiency. B12 and folate are involved in the synthesis of thymidine Impaired DNA synthesis causes a delay in mitotic division Nucleus does not mature appropriately, cytoplasmic maturation proceeds normally.
