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Rolling circle replication (RCR) is a process of unidirectional nucleic acid replication that can rapidly synthesize multiple copies of circular molecules of DNA or RNA, such as plasmids, the genomes of bacteriophages, and the circular RNA genome of viroids. Some eukaryotic viruses also replicate their DNA or RNA via the rolling circle mechanism.
Rolling-circle replication is involved in various processes conducted by genetic elements, including (i) replication of their autonomous forms (plasmids, bacteriophages, viruses and ICEs), (ii) conjugal transfer (plasmids, ICEs), (iii) transposition (TEs), and (iv) recombination.
Rolling-circle replication (RCR) is a mechanism adopted by certain plasmids, among other genetic elements, that represents one of the simplest initiation strategies, that is, the nicking by a replication initiator protein on one parental strand to generate the primer for leading-strand initiation and a single priming site for lagging-strand ...
Figure \(\PageIndex{24}\): Rolling Circle Replication. The process of rolling circle replication is initiated by a single stranded nick in the DNA. Within prokaryotes, DNA polymerase III is utilized to generate the daughter strand.
Rolling-circle replication (RCR) is a mechanism adopted by certain plasmids, among other genetic elements, that represents one of the simplest initiation strategies, that is, the nicking by a replication initiator protein on one parental strand to generate the primer for leading-strand initiation and a single priming site for lagging-strand ...
Apr 21, 2024 · Rolling circle replication is a type of rapid unidirectional DNA synthesis of a circular DNA molecule used for the replication of some plasmids.
Nov 11, 2016 · DNA polymerase “rolling circle” activities were discovered concurrently in our laboratory and that of Andrew Fire. We describe the surprising efficiency of this process even on shockingly small circular DNAs, producing repeating DNAs thousands of nucleotides in length.
