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A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains.
Mar 9, 2016 · Howell-Jolly bodies occur where there is no spleen or an non-functioning spleen, referred to as asplenia. They are usually one of these at most in a red cell, round, dark purple to red in color and often located peripherally on the red blood cell.
Sep 18, 2022 · Howell-Jolly bodies appear in peripheral blood smears in patients with absent or deficient spleen function. They are pathognomonic for splenic dysfunction but can be found in a long list of disorders: Post-splenectomy. Sepsis. Congenital disorders.
- Jason M. Scafidi, Vikas Gupta
- 2022/09/18
- 2021
Nov 14, 2022 · Howell-Jolly bodies are solid, large, round masses found in the hemoglobin of the cell and are visualized with Wright-stain and have many clinical significances. Pappenheimer bodies are multiple, small blue inclusion bodies throughout the entire RBC indicating iron overload, hyposplenism or myelodysplasia.
- Laura Barbalato, Leela Sharath Pillarisetty
- Midland Memorial / Texas Tech University
- 2019
- 2022/11/14
Learn about the different types of RBC inclusion bodies, such as Howell-Jolly bodies, and how they indicate various hematological disorders. Find out how to identify and interpret RBC morphology on blood smears.
Northern Alberta Institute of Technology via Open Education Alberta. Appearance: Under Wright/Romanowksy stains, Howell-Jolly Bodies appear as dark blue/purple round inclusions located at the periphery of the RBC. They usually present as a single inclusion inside the cell.
Howell-Jolly bodies are nuclear fragments or remnants inside red blood cells. They are associated with various diseases such as thalassemia, megaloblastic anemia, and post-splenectomy.
