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Articles 1–20. Faculty of Pharmacy, Tabriz University of Medical Sciences - Cited by 18,325 - Pharmaceutical nanotechnology - Smart drug delivery systems - Nanostructured polymeric...
Soodabeh Davaran (Persian: سودابه داوران) is an Iranian researcher, and professor of polymer chemistry in the Faculty of Pharmacy in Tabriz University of Medical Sciences. She has written many articles about chemistry. Some of her scientific articles have been retracted because of figure manipulation and misconduct.
Jan 1, 2023 · Soodabeh Davaran. Doctorate. Professor. Primary. Tabriz University of Medical Sciences. Tabriz, Iran. Adjunct Professor. Yeditepe University. Istanbul, Türkiye.
- Introduction
- Classification of Liposomes
- Methods of Liposome Preparation
- Stealth Liposomes and Conventional Liposomes
- Applications of Liposomes in Medicine and Pharmacology
Liposomes are small artificial vesicles of spherical shape that can be created from cholesterol and natural non-toxic phospholipids. Due to their size and hydrophobic and hydrophilic character(besides biocompatibility), liposomes are promising systems for drug delivery. Liposome properties differ considerably with lipid composition, surface charge,...
The liposome size can vary from very small (0.025 μm) to large (2.5 μm) vesicles. Moreover, liposomes may have one or bilayer membranes. The vesicle size is an acute parameter in determining the circulation half-life of liposomes, and both size and number of bilayers affect the amount of drug encapsulation in the liposomes. On the basis of their si...
General methods of preparation
All the methods of preparing the liposomes involve four basic stages: 1. 1. Drying down lipids from organic solvent. 2. 2. Dispersing the lipid in aqueous media. 3. 3. Purifying the resultant liposome. 4. 4. Analyzing the final product.
Method of liposome preparation and drug loading
The following methods are used for the preparation of liposome: 1. 1. Passive loading techniques 2. 2. Active loading technique. Passive loading techniques include three different methods: 1. 1. Mechanical dispersion method. 2. 2. Solvent dispersion method. 3. 3. Detergent removal method (removal of non-encapsulated material) [18, 19].
Mechanical dispersion method
The following are types of mechanical dispersion methods: 1.1. Sonication. 1.2. French pressure cell: extrusion. 1.3. Freeze-thawed liposomes. 1.4. Lipid film hydration by hand shaking, non-hand. shaking or freeze drying. 1.5. Micro-emulsification. 1.6. Membrane extrusion. 1.7. Dried reconstituted vesicles[18, 19]. Sonication is perhaps the most extensively used method for the preparation of SUV. Here, MLVs are sonicated either with a bath type sonicator or a probe sonicator under a passive a...
Although liposomes are like biomembranes, they are still foreign objects of the body. Therefore, liposomes are known by the mononuclear phagocytic system (MPS) after contact with plasma proteins. Accordingly, liposomes are cleared from the blood stream. These stability difficulties are solved through the use of synthetic phospholipids, particle coa...
Applications of liposomes in medicine and pharmacology can be divided into diagnostic and therapeutic applications of liposomes containing various markers or drugs, and their use as a tool, a model, or reagent in the basic studies of cell interactions, recognition processes, and mode of action of certain substances. Unfortunately, many drugs have a...
- Abolfazl Akbarzadeh, Rogaie Rezaei-Sadabady, Rogaie Rezaei-Sadabady, Soodabeh Davaran, Sang Woo Joo,...
- 2013
Soodabeh DAVARAN, researcher | Cited by 13,507 | of Tabriz University of Medical Sciences, Tabriz (TBZMED) | Read 237 publications | Contact Soodabeh DAVARAN
Davaran: With Siamak Adib, Masoud Agahi, Ayoub Aghakhani, Siamak Atlassi. The story of this series is about a family consisting of judges and lawyers who are involved in special cases in each episode.
Dr. Davaran is the head of Medicinal Nanotechnology Department of Pharmaceutics College of Tabriz University of Medical Sciences and the professor of medicinal biomaterials and medicinal nanotechnology of the university.
