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In toxicology, the median lethal dose, LD50 (abbreviation for " lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. [1] . The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
May 10, 2024 · The LD 50 is one way to measure the short-term poisoning potential (acute toxicity) of a material. Toxicologists can use many kinds of animals but most often testing is done with rats and mice.
Feb 11, 2018 · The median lethal dose, or LD50, is a term used in toxicology as a measurement of a lethal dose of a substance (e.g., pathogen, medication, toxic substance, etc.). Specifically, the LD50 represents the dose at which a substance is lethal for 50% of tested subjects.
The LD50 has been defined as the median lethal dose of a material that will kill 50% of the animals. Acute studies may also indicate probable target organs and provide guidance on doses to be used in longer duration studies.
The LD 50 is usually expressed as the mass of substance administered per unit mass of test subject, typically as milligrams of substance per kilogram of body mass, but stated as nanograms (suitable for botulinum ), micrograms, milligrams, or grams (suitable for paracetamol) per kilogram.
Jan 1, 2024 · The amount of a chemical agent that is expected to kill 50% of the test organisms when given directly under the test’s stated conditions. For many years, the gold standard for determining acute toxicity between toxicants and species was the LD50 value, first created in 1927.
Dec 21, 2020 · Acute lethality provides one simple, generalized indicator of the toxicity of a chemical product. The acute lethality hazard is typically determined using the LD 50 which is defined as the median dose predicted to kill 50% of a given test population.
The LD 50 is the dose that kills half (50%) of the animals tested (LD = "lethal dose"). The animals are usually rats or mice, although rabbits, guinea pigs, hamsters, and so on are sometimes used. In all these tests, the dose must be calculated relative to the size of the animal.
Jun 20, 2014 · The median lethal dose of a substance, or the amount required to kill 50% of a given test population. LD50 is a measurement used in toxicology studies to determine the potential impact of toxic substances on different types of organisms.
Jun 18, 2024 · TD50: The Therapeutic Dose is the dose of a chemical that causes a therapeutic effect in 50% of a test population. EC50: The Effective Concentration is the concentration of a chemical in air or water that causes a specific effect, such as death or changes in behavior, in 50% of a test population.
