Lamont Dixon
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Nov 28, 2023 · The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches.
PSI-BLAST allows the user to build a PSSM (position-specific scoring matrix) using the results of the first BlastP run. PHI-BLAST performs the search but limits alignments to those that match a pattern in the query.
Local alignments algorithms (such as BLAST) are most often used. A global alignment should only be used on sequences that share significant similarity over most of their extents, and then it will sometimes return a better presentation.
The program compares nucleotide or protein sequences to sequence in a database and calculates the statistical significance of the matches. This chapter first provides an introduction to BLAST and then describes the practical application of different BLAST programs based on the BLAST Quick Start mini-course (www.ncbi.nlm.nih.gov/Class/minicourses).
Primer-blast tries to find target-specific primers by placing candidate primers on unique template regions that are not similar to other targets.
In order to run BLAST locally on your own computer, you will need to download the BLAST+ software and databases. To see the instructions and get the latest version of BLAST+, go to the BLAST download page.
Jun 23, 2008 · Sequence similarity searching is one of the more important bioinformatics activities and often provides the first evidence for the function of a newly sequenced gene or piece of sequence. Basic Local Alignment Search Tool (BLAST) is probably the most popular similarity search tool.
Awash in a sea of data, how do scientists identify the function of a newly cloned gene? Online resources like the Basic Local Alignment Search Tool (BLAST) provide a helping hand.
Magic-BLAST ¶ Magic-BLAST is a tool for mapping large next-generation RNA or DNA sequencing runs against a whole genome or transcriptome. Read more about Magic-BLAST at NCBI Magic-BLAST Documentation. Installers and source code are available from https://ftp.ncbi.nlm.nih.gov/blast/executables/magicblast/LATEST. IgBLAST ¶
Aug 3, 2023 · BLAST stands for Basic Local Alignment Search Tool. It is a widely used bioinformatics program that was first introduced by Stephen Altschul et al. in 1990 and has since become one of the most popular tools for sequence similarity search.
