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Abstract. Background: Dotinurad is a novel selective urate reabsorption inhibitor that reduces serum urate levels in hyperuricemic patients with or without gout by selectively inhibiting urate transporter 1. This study was conducted to compare the efficacy and safety of dotinurad with those of benzbromarone.
- Tatsuo Hosoya, Takafumi Sano, Tomomitsu Sasaki, Masahiko Fushimi, Tetsuo Ohashi
- 2020
This study was intended to verify the efficacy and safety of dotinurad following treatment for 34 or 58 weeks in hyperuricemic patients with or without gout. Methods: This long-term study had an open-label design with dose escalation.
- Tatsuo Hosoya, Masahiko Fushimi, Daisuke Okui, Tomomitsu Sasaki, Tetsuo Ohashi
- 2020
Background: Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by selective inhibition of the urate transporter 1. We evaluated the efficacy and safety of dotinurad versus febuxostat, a widely used drug in Japan, in hyperuricemic Japanese patients with or without gout.
- Tatsuo Hosoya, Kazuki Furuno, Shingo Kanda
- 2020
Tatsuo Hosoya's 422 research works with 11,926 citations and 11,057 reads, including: Changes in erythropoiesis‐stimulating agent responsiveness after transfer to combined therapy with ...
Dec 26, 2019 · Hosoya T, Ohno I, Nomura S, et al. Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout. Clin Exp Nephrol. 2014; 18:876–884. doi: 10.1007/s10157-014-0935-8. [PMC free article] [Google Scholar]
- Tatsuo Hosoya, Masahiko Fushimi, Daisuke Okui, Tomomitsu Sasaki, Tetsuo Ohashi
- 10.1007/s10157-019-01831-5
- 2020
- Clin Exp Nephrol. 2020; 24(Suppl 1): 80-91.
Jan 24, 2020 · Dotinurad is a novel selective urate reabsorption inhibitor that reduces serum urate levels in hyperuricemic patients with or without gout by selectively inhibiting urate transporter 1. This study was conducted to compare the efficacy and safety of dotinurad with those of benzbromarone. Methods.
Jun 9, 2014 · Recently, common dysfunctional variants of ABCG2, a urate exporter gene also known as BCRP, are revealed to be a major cause of gout/hyperuricemia. Here, we compared the influence of ABCG2 ...
