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Mauvoisin et al. provide a rhythmic acetylome map of the mouse liver. Rhythmic acetylated proteins showed subcellular localization-specific phases with an over-representation of SIRT3 targets. Feeding rhythms and the circadian clock regulate NAD+ synthesis through the salvage and nicotinamide riboside pathways, affecting metabolite accumulation.
- Daniel Mauvoisin, Daniel Mauvoisin, Florian Atger, Florian Atger, Loïc Dayon, Antonio Núñez Galindo,...
- 2017
Nov 3, 2016 · To measure the diurnal accumulation of proteins in the nucleus of mouse liver, we designed a quantitative SILAC mass spectrometry (MS) experiment in which nuclear protein extracts were harvested from mice liver every 3 hr for 2 days, yielding two biological replicates at each of eight time points.
- Jingkui Wang, Daniel Mauvoisin, Eva Martin, Florian Atger, Florian Atger, Antonio Núñez Galindo, Loï...
- 2017
Jan 7, 2014 · Authors. Daniel Mauvoisin 1 , Jingkui Wang , Céline Jouffe , Eva Martin , Florian Atger , Patrice Waridel , Manfredo Quadroni , Frédéric Gachon , Felix Naef. Affiliation. 1 Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland. PMID: 24344304. PMCID: PMC3890886. DOI: 10.1073/pnas.1314066111. Abstract.
Jan 1, 2014 · PMID: 24344304. Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Daniel Mauvoisin, a,b,1 Jingkui Wang, c,1 Céline Jouffe, a,b Eva Martin, a,b Florian Atger, a,b Patrice Waridel, d Manfredo Quadroni, d Frédéric Gachon, a,b,1,2 and Felix Naef c,1,2.
Proteomic technologies using MS offer new perspectives in circadian biology, in particular the possibility to study PTMs. To date, only very few studies have been carried out to decipher the rhythmicity of protein expression in mammals with large‐scale proteomics.
Jan 10, 2017 · Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (. Robles et al., 2016. , Wang et al., 2016. ) reveal extensive circadian regulation of the nuclear and phosphoproteome.
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