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2 days ago · The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been shown to inhibit replication of a broad range of viruses that rely on ER protein quality control. We found, by screening a panel of deoxynojirimycin and cyclitol glycomimetics, that the mechanism-based ER α-glucosidase II inhibitor, 1,6-epi-cyclophellitol cyclosulfate, potently blocks SARS-CoV-2 replication in lung epithelial cells, halting intracellular generation of mature spike protein, reducing ...
3 days ago · Background Hydroxychloroquine (HCQ) is recommended for Chinese patients with immunoglobulin A nephropathy (IgAN). However, the relationship between HCQ blood concentration and the therapeutic effect for IgAN has not yet been defined. This study investigates the optimal and efficacious range of HCQ blood concentrations in Chinese patients with IgAN. Methods Seventy-three patients with biopsy-proven IgAN who were at risk of progression were included in this study. Thirty-eight patients with ...
2 days ago · Alexander Clavel-Respinger (1881–1973), Schweizer Textil- und Färberei-Industrieller; Alexander S. Clay (1853–1910), US-amerikanischer Politiker der Demokratischen Partei; Alexander Mosby Clayton (1801–1889), US-amerikanischer Politiker; Alexander Clutterbuck (1897–1975), britischer Diplomat und Regierungsbeamter
3 days ago · Olivia Clavel-Davis (Skyline Theatre Company's Little Women), Brian Dauglash ... Russ Anixter is the Copyist, and Alexander Greenberg is the Music Assistant and Keyboard Programmer.
1 day ago · Alexander "Sascha" Zverev (German pronunciation: [alɛkˈsandɐ ˈtsfeːʁɛf]; born 20 April 1997) is a German professional tennis player. He has been ranked by the ATP as high as world No. 2. Zverev's singles career highlights include a gold medal at the 2020 Tokyo Olympics , and titles at the 2018 and the 2021 ATP Finals .
12 hours ago · Rudy Clavel : 29 FW SLV ... Alexander Méndoza: 2014–2015 Luis Edgardo Contreras 2015–2016 Néstor Renderos: 2017–2019 Xavier García: 2019-2021
6 days ago · Dillon Brooks con 21 punti, 5 rimbalzi e 3 assist è stato il miglior realizzatore per il Team Canada, mentre Alexander-Walker (15 punti), Lyles (15 punti), Barrett (14 punti, 7 rimbalzi, 4 punti) e Gilgeous-Alexander (14 punti, 6 punti, 3 rimbalzi) sono andati in doppia cifra.
