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Chinese hamster ovary ( CHO) cells are a family of immortalized cell lines [1] derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.
Chinese hamster ( Cricetulus griseus) ovary (CHO) cells, a mammalian cell line, are the equivalent of E. coli in research and biotechnology due to the extensive research and industrial attention they have received.
The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of the therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein.
The evolution of CHO cells’. role in cell line development. Since the first approval of recombinant insulin and human growth hormone in the early 1980s, a multitude of recombinant protein therapeutics have been approved by regulatory agencies, notably the FDA in the US and EMA in Europe.
Jul 21, 2013 · Chinese hamster ovary (CHO) cells, first isolated in 1957, are the preferred production host for many therapeutic proteins.
Feb 25, 2022 · To date, the most widely used CHO cell lines include HCO-K1, CHO DXB11, CHO-S, and CHO DG44, all of which exhibit different karyogram and epigenetic variations that contribute to their individual properties.
Feb 17, 2021 · Several CHO cell lines have been developed to date; CHO-K1 and CHOK1SV are frequently used to produce biotherapeutics. CHO cell lines have been genetically engineered to increase productivity, reduce apoptosis, and improve glycosylation (Zhu et al. 2017).
Aug 30, 2022 · Chinese hamster ovary cells (CHO) as the main production hosts offer a variety of advantages including robust growth and survival in a bioprocess environment.
Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of producing high quality biologics exhibiting human-like post-translational modifications in gram quantities.
Jan 27, 2023 · Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the biopharmaceutical industry.
