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Karl Fischer Titration is a popular analytical method used for the determination of water content in various industries, including food, beverage, cosmetics, chemicals, and pharmaceuticals. The method is efficient, rapid, and accurate, making it the most important method for determining water content. The traditional drying oven technique is ...
What is the Karl Fischer Method? As shown in Formula (1) below, the Karl Fischer method uses Karl Fischer reagent, which reacts quantitatively and selectively with water, to measure moisture content. Karl Fischer reagent consists of iodine, sulfur dioxide, a base and a solvent, such as alcohol. I 2 +SO 2 +3Base+ROH+H 2 O ⇒ 2Base+HI+Base+HSO 4 ...
Karl Fischer (24 March 1901 – 16 April 1958) was a German chemist. In 1935 he published a method to determine trace amounts of water in samples. [2] This method is now called Karl Fischer titration and was originally performed manually but has been automated.
The amount of water present in the sample is calculated based on the concentration of iodine in the Karl Fisher titrating reagent (i.e., titer) and the amount of Karl Fisher Reagent consumed in the titration. EMD Chemicals Inc. 480 South Democrat Road Gibbstown, NJ 08027. Phone: 856-423-6300 Fax: 856-423-4389 www.emdchemicals.com.
Karl Fischer titration is used for many substances as a reference method, and is a chemical analysis based on the oxidation of sulfur dioxide by iodine in a methanolic hydroxide solution. In principle, the following chemical reaction takes place: H 2 O + I 2 + SO 2 + CH 3 OH + 3RN -> [RNH]SO 4 CH 3 + 2[RNH]I The titration can be performed volumetrically or coulometrically.
The Volumetric Compact Karl Fischer Titrators have been designed for a wide range of water content applications: determinations from 100 ppm to 100% water – fast and precisely. The titration vessel is optimized to retain a low drift value and offers the possibility to determine the water content of liquid, solid and gaseous samples.
May 18, 2018 · Water content by Karl Fischer (Titrimetric) Mix and accurately weigh the substance to be tested, and, unless otherwise directed in the individual monograph, conduct the determination on 1 to 2 g. If the test specimen is in the form of large crystals, reduce the particle size to about 2 mm by quickly crushing.
