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Apr 30, 2024 · In this framework, we found a consistent association between RAASi and HF outcomes, closely mirroring the findings from the INTERMACS registry, where patients receiving RAASi at 6 months had better 4‐year survival and RAASi portended the greatest mortality risk reduction among neurohormonal blocking agents, 8 and those of the International Society for Heart and Lung Transplantation Mechanically Assisted Circulatory Support registry were patients receiving RAASi at 3 months who had improved ...
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Abstract. Renin-angiotensin-aldosterone system inhibitors (RAASi) reduce morbidity and mortality in heart failure (HF) with reduced ejection fraction in a dose-dependent manner. They also have a positive impact in other cardiovascular diseases (CVDs). However, RAASi may induce hyperkalemia, a potentially life-threatening disorder.
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Jan 19, 2023 · Background. Hyperkalemia (HK) is a barrier to optimization of renin-angiotensin-aldosterone system inhibitor (RAASi) therapy in heart failure (HF) and chronic kidney disease (CKD). We investigated cardiorenal risk associated with changes in RAASi regimen after an episode of HK in patients with HF and/or CKD.
RAASi appear to be underused, even among patients with strong class-specific recommendations. Although the reasons for this variation could not be fully identified in this cross-sectional observation, our data indicate that the risk of hyperkalemia may contribute to the underuse of this class of agents in moderate to advanced CKD.
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