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Feb 17, 2021 · The basement membrane (BM) is a special type of extracellular matrix that lines the basal side of epithelial and endothelial tissues. Functionally, the BM is important for providing physical and biochemical cues to the overlying cells, sculpting the tissue into its correct size and shape.
Jul 15, 2022 · Advancements in the field of tissue engineering have led to the elucidation of physical and chemical characteristics of physiological basement membranes (BM) as specialized forms of the extracellular matrix. Efforts to recapitulate the intricate structure and biological composition of the BM have encountered various advancements due to its impact on cell fate, function, and regulation. More attention has been paid to synthesizing biocompatible and biofunctional fibrillar scaffolds that ...
Feb 10, 2017 · Basement membranes provide structural support to epithelium, endothelium, muscles, fat cells, Schwann cells, and axons. Basement membranes are multifunctional: they modulate cellular behavior, regulate organogenesis, promote tissue repair, form a barrier to filtration and tumor metastasis, bind growth factors, and mediate angiogenesis.
May 14, 2018 · Basement membranes are components of the extracellular matrix and help to regulate passage of materials between epithelial cells and adjacent blood vessels. Each consists of a framework of collagen fibrils, within which are glycosaminoglycans (mucopolysaccharides) and laminins, which are proteins that bind the basement membrane to neighbouring cells via cell adhesion molecules .
Basement membranes are thin sheets of specialised extracellular matrix, supporting epithelial cell layers and covering muscle cells and nerve fibres. Basement membranes not only provide a particular support for tissues, but also have essential roles in cell...
Nov 21, 2023 · The basement membrane is composed of a matrix of strong extracellular substances including collagen, laminin, and glycoproteins. This composition provides a durable structural base for epidermal ...
May 1, 2015 · Basement membranes are a dense, sheet-like form of extracellular matrix (ECM) that underlie epithelia and endothelia, and surround muscle, fat and Schwann cells. Basement membranes separate tissues and protect them from mechanical stress. Although traditionally thought of as a static support structure, a growing body of evidence suggests that ...
